Am J Clin Pathol. 2005 Dec;124 Suppl:S110-21.
“Undifferentiated” small round cell tumors of the sinonasal
tract: differential diagnosis update.
Iezzoni JC, Mills SE.
Robert E. Fechner Laboratory of Surgical Pathology, Department of
Pathology, University of Virginia Health System, Charlottesville 22908,
Sinonasal tract neoplasms composed of light microscopically seemingly
“undifferentiated” small round cells often generate considerable
diagnostic difficulty. Although the careful review of H&E-stained
sections remains of critical and central importance in this evaluation,
the recent improvements in the immunohistochemical diagnostic
armamentarium and molecular diagnostic techniques applicable to
paraffin-embedded tissue samples may add diagnostically valuable
information. Accordingly, this review will discuss the differential
diagnosis of undifferentiated small blue cell tumors of the sinonasal
tract based on the light microscopic and clinical features and, as
needed, the results of these ancillary studies. Tumors discussed
include olfactory neuroblastoma, sinonasal undifferentiated carcinoma,
small cell undifferentiated (neuroendocrine) carcinoma,
undifferentiated (lymphoepithelioma-like) carcinoma, malignant
melanoma, pituitary adenoma, Ewing sarcoma/peripheral neuroectodermal
tumor, rhabdomyosarcoma, mesenchymal chondrosarcoma, small cell
osteosarcoma, synovial sarcoma, extranodal natural killer/T-cell
lymphoma, nasal type, and extramedullary plasmacytoma.
PMID: 16468421 [PubMed – in process]